Análise de elasticidade para sistemas agrícolas da planície do norte da China baseada em um modelo dinâmico de sistema

Este trabalho se refere a um estudo de caso da teoria de elasticidade para entender sistemas agrícolas na província de Luancheng na planície do norte da China. Foi construído um modelo de sistema dinâmico acoplado a subsistemas agrícolas sociais, econômicos e ecológicos para a província de Luancheng com um intervalo de tempo de um mês. O modelo inclui cinco componentes principais: recursos hídricos, rentabilidade, irrigação, produção agrícola e área. O lençol freático simulado, a área e a produção de trigo, a área e produção de milho e a transferência de mão de obra refletiram a tendência geral dos resultados observados com coeficientes de determinação maiores que 0.88. A elasticidade dos sistemas agrícolas, indicada pela rentabilidade e segurança alimentar, foi explorada para a província de Luancheng, que mostrou que inicialmente os investimentos em agricultura tiveram sua elasticidade aumentada rapidamente. Entretanto, com a degradação dos recursos e o aumento do investimento agrícola, o custo da produção agrícola tornou-se muito alto para obtenção de lucro. O aumento de população aumenta o risco de segurança alimentar. Como resultado, a elasticidade dos sistemas agrícolas decresceu gradualmente. A província de Luancheng encontra-se agora na fase conservativa do ciclo de adaptação. Ajustes parciais deveriam ser implementados para impulsionar sua elasticidade e promover o desenvolvimento contínuo dos sistemas agrícolas.This paper presents a case study of resilience theory to understand agricultural systems in the Luancheng County of the North China Plain. A dynanic system model coupled with social, economic and ecological subsystems of agriculture for the Luancheng County was constructed with a time step of one month. The model includes five main components, water resources, profitability, irrigation, crop yield and area. The simulated groundwater table, wheat area and yield, maize area and yield, and rural labor transfer reflected the general trend of the observed data, with calculated determination coefficients higher than 0.88. Resilience of agricultural systems, as indicated by agricultural profitability and food security, were explored for the Luancheng County. Initially, investments in agriculture increased its resilience rapidly. However, with the degradation of resources and the increases in agricultural investment, the cost of agricultural production became too high to gain profit. The rise in population increases the risk of food security. As a result, the resilience of agricultural systems decreased gradually. The Luancheng County is now in the conservation phase of the adaptive cycle. Partial adjustments should be introduced to enhance its resilience and promote the continuing development of the agricultural systems

A knee-point-based evolutionary algorithm using weighted subpopulation for many-objective optimization

The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.Among many-objective optimization problems (MaOPs), the proportion of nondominated solutions is too large to distinguish among different solutions, which is a great obstacle in the process of solving MaOPs. Thus, this paper proposes an algorithm which uses a weighted subpopulation knee point. The weight is used to divide the whole population into a number of subpopulations, and the knee point of each subpopulation guides other solutions to search. Besides, Additionally, the convergence of the knee point approach can be exploited, and the subpopulation-based approach improves performance by improving the diversity of the evolutionary algorithm. Therefore, these advantages can make the algorithm suitable for solving MaOPs. Experimental results show that the proposed algorithm performs better on most test problems than six other state-of-the-art many-objective evolutionary algorithms

Electroconvulsive therapy for agitation in schizophrenia: Meta-analysis of randomized controlled trials

Background: Agitation poses a significant challenge in the treatment of schizophrenia. Electroconvulsive therapy (ECT) is a fast, effective and safe treatment for a variety of psychiatric disorders, but no meta-analysis of ECT treatment for agitation in schizophrenia has yet been reported. Aims: To systematically evaluate the efficacy and safety of ECT alone or ECT-antipsychotics (APs) combination for agitation in schizophrenia. Methods: Systematic literature search of randomized controlled trials (RCTs) was performed. Two independent evaluators selected studies, extracted data about outcomes and safety with available data, conducted quality assessment and data synthesis. The Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) was used to judge the level of the overall evidence of main outcomes. Results: Seven RCTs from China, including ECT alone (4 RCTs with 5 treatment arms, n=240) and ECT-APs combination (3 RCTs, n=240), were identified. Participants in the studies were on average 34.3(4.5) years of age and lasted an average of 4.3(3.1) weeks of treatment duration. All 7 RCTs were non-blinded, and were rated as low quality based on Jadad scale. Meta-analysis of the pooled sample found no significant difference in the improvement of the agitation sub-score of the Positive and Negative Syndrome Scale (PANSS) when ECT alone (weighted mean difference=-0.90, (95% confidence interval (CI): -2.91, 1.11), p=0.38) or ECT-APs combination (WMD=-1.34, (95%CI: -4.07, 1.39), p=0.33) compared with APs monotherapy. However, ECT alone was superior to APs monotherapy regarding PANSS total score (WMD=-7.13, I2=0%, p=0.004) and its excitement sub-score (WMD=-1.97, pI2=0%, p=0.004) and its excitement sub-score at 7 and 14 days (WMD=-1.97 to -1.92, p=0.002 to 0.0001) after ECT. The ECT-APs combination was superior to APs monotherapy with respect to the PANSS total score at treatment endpoint (WMD=-10.40, p=0.03) and 7 days (WMD=-5.01, p=0.02). Headache ( number-needed-to-harm (NNH)=3, 95%CI=2-4) was more frequent in the ECT alone group compared to AP monotherapy. According to the GRADE approach, the evidence levels of main outcomes were rated as ‘‘very low’’ (37.5%) and “low” (50%). Conclusion: Pooling of the data based on 7 RCTs from China found no advantage of ECT alone or ECT-APs combination in the treatment of agitation related outcomes in schizophrenia patients. However, ECT alone or ECT-APs combination were associated with significant reduction in the PANSS total score. High-quality RCTs are needed to confirm the current interpretations. Review registration number: CRD4201400668

A novel algicidal properties of fermentation products from Pseudomonas sp. Ps3 strain on the toxic red tide dinoflagellate species

The viability of both China’s offshore fishing operations and the global marine fishing industry is threatened by the occurrence of red tides caused by Gymnodinium catenatum and Karenia mikimotoi. Effective control of these dinoflagellate-mediated red tides has become a pressing issue that requires immediate attention. In this study, High-efficiency marine alginolytic bacteria were isolated and underwent molecular biological identification to confirm their algicidal properties. Based on a combination of morphological, physiological, biochemical, and sequencing results, Strain Ps3 was identified as belonging to the species Pseudomonas sp. We examine the effects of algicidal bacteria on the red tide species G. catenatum and K. mikimotoi within an indoor experimental setting. Then gas chromatography– mass spectrometry (GC–MS) was used to analyze the structure of the algolytic active substances. This investigation demonstrated that with exposure to the algae-lysis experiment, the Ps3 strain has the best algae-lysis effect, with G. catenatum and K. mikimotoi reaching 83.0 and 78.3%. Our results from the sterile fermentation broth experiment showed that the inhibitory effect on the two red tide algae was positively correlated with the concentration of the treatment. At a treatment concentration of 2.0% (v/v), the 48 h lysis rates of G. catenatum and K. mikimotoi due to exposure to the Ps3 bacterial fermentation broth were 95.2 and 86.7%, respectively. The results of this study suggest that the algaecide may be a rapid and effective method to control dinoflagellate blooms, as evidenced by the observed changes in cellular morphology in all cases. In the ethyl acetate phase of Ps3 fermentation broth, the cyclic (leucine-leucine) dipeptide was the most abundant. The findings of this study contribute to our understanding of red tide prevention and control and provide a theoretical foundation for further research in this field

Serum retinol-binding protein 4 levels are elevated but do not contribute to insulin resistance in newly diagnosed Chinese hypertensive patients

BACKGROUND: Insulin resistance (IR) is closely correlated with cardiovascular disease (CVD). Retinol-binding protein 4 (RBP4) is a novel adipokine that modulates the action of insulin in various diseases. This study addressed the relationship between RBP4 and IR in newly diagnosed essential hypertension. METHODS: Serum RBP4, anthropometric and metabolic parameters were determined in 267 newly diagnosed essential hypertensive patients not taking antihypertensive medications. The patients along with 64 control (NC) normotensive and lean subjects paired by age and sex were divided into two groups depending on body mass index (BMI), hypertension with obesity (HPO) and hypertension without obesity (HP). RESULTS: A striking difference was observed in RBP4 levels between the HP and NC groups. Significantly higher levels were noted in the HP group compared with the NC group; slightly, but not significantly, lower levels were observed in the HPO group compared with the HP group. After adjusting for BMI, WC and WHR, a modestly linear relationship was observed between RBP4 levels and SBP (r = 0.377; p = 0.00), DBP (r = 0.288; p = 0.00) and HOMA-β(r = 0.121; p = 0.028). Multiple stepwise regression analysis showed that SBP, WHR and drinking were independently related with serum RBP4 levels. CONCLUSIONS: The results of this study indicated that RBP4 levels were increased in naive hypertensive patients; however, no differences were observed in obese or non-obese hypertensive subjects. Our data suggest for the first time that RBP4 levels are significantly increased but do not contribute to the development of IR in newly diagnosed hypertensive Chinese patients

Adaptive neighborhood selection for many-objective optimization problems

The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI linkIt is generally accepted that conflicts between convergence and distribution deteriorate with an increase in the number of objectives. Furthermore, Pareto dominance loses its effectiveness in many-objectives optimization problems (MaOPs), which have more than three objectives. Therefore, a more valid selection method is needed to balance convergence and distribution. This paper presents a many-objective evolutionary algorithm, called Adaptive Neighborhood Selection for Many-objective evolutionary algorithm(ANS-MOEA), to deal with MaOPs. This method defines the performance of each individual by two types of information, convergence information (CI) and distribution information (DI). In the critical layer, a well-converged individual is selected first from the population, and its neighbors, calculated by DI, are pushed into neighbor collection (NC) soon afterwards. Then, the proper distribution of the population is ensured by competition individuals with large DI go back to the population and individuals with small DI remain in the collection. Four state-of-the-art MaOEAs are selected as the competitive algorithms to validate ANS-MOEA. The experimental results show that ANS-MOEA can solve a MaOP and generate a set of remarkable solutions to balance convergence and distribution

Decreased Peripheral BDNF Levels and Cognitive Impairment in Late-Life Schizophrenia

Objectives: There are relatively few studies on mechanisms of cognitive deficits in late-life schizophrenia (LLS). Brain-derived neurotrophic factor (BDNF), as an important neuroplastic molecule, has been reported to be involved in neurocognitive impairment in schizophrenia. This study aimed to examine whether peripheral BDNF levels were associated with cognitive deficits in LLS, which has not been explored yet.Methods: Forty-eight LLS patients and 45 age-matched elderly controls were recruited. We measured all participants on the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) for cognition and serum BDNF levels. Psychopathological symptoms in patients were assessed by the Positive and Negative Syndrome Scale (PANSS).Results: The levels of BDNF in LLS patients were significantly lower than those in healthy controls (8.80 ± 2.30 vs. 12.63 ± 5.08 ng/ml, p < 0.001). The cognitive performance of LLS patients was worse than that of the controls on RBANS total score and scores of immediate memory, attention, language, and delayed memory (all p ≤ 0.005). BDNF was positively associated with attention in LLS patients (r = 0.338, p = 0.019).Conclusion: Our findings suggest that older patients with schizophrenia exhibit lower BDNF levels and more cognitive deficits than older controls, supporting the accelerated aging hypothesis of schizophrenia. Moreover, decreased BDNF is related to attention deficits, indicating that BDNF might be a candidate biomarker of cognitive impairments in LLS patients

Development and validation of nomogram models to predict radiotherapy or chemotherapy benefit in stage III/IV gastric adenocarcinoma with surgery

ObjectivesThe advanced gastric adenocarcinoma (GAC) patients (stage III/IV) with surgery may have inconsistent prognoses due to different demographic and clinicopathological factors. In this retrospective study, we developed clinical prediction models for estimating the overall survival (OS) and cancer-specific survival (CSS) in advanced GAC patients with surgeryMethodsA retrospective analysis was conducted using the Surveillance, Epidemiology, and End Results (SEER) database. The total population from 2004 to 2015 was divided into four levels according to age, of which 179 were younger than 45 years old, 695 were 45-59 years old, 1064 were 60-74 years old, and 708 were older than 75 years old. There were 1,712 men and 934 women. Univariate and multivariate Cox regression analyses were performed to identify prognostic factors for OS and CSS. Nomograms were constructed to predict the 1-, 3-, and 5-year OS and CSS. The models’ calibration and discrimination efficiency were validated. Discrimination and accuracy were evaluated using the consistency index, area under the receiver operating characteristic curve, and calibration plots; and clinical usefulness was assessed using decision curve analysis. Cross-validation was also conducted to evaluate the accuracy and stability of the models. Prognostic factors identified by Cox regression were analyzed using Kaplan-Meier survival analysis.ResultsA total of 2,646 patients were included in our OS study. Age, primary site, differentiation grade, AJCC 6th_TNM stage, chemotherapy, radiotherapy, and number of regional nodes examined were identified as prognostic factors for OS in advanced GAC patients with surgery (P < 0.05). A total of 2,369 patients were included in our CSS study. Age, primary site, differentiation grade, AJCC 6th_TNM stage, chemotherapy, radiotherapy, and number of regional nodes examined were identified as risk factors for CSS in these patients (P < 0.05). These factors were used to construct the nomogram to predict the 1-, 3-, and 5-year OS and CSS of advanced GAC patients with surgery. The consistency index and area under the receiver operating characteristic curve demonstrated that the models effectively differentiated between events and nonevents. The calibration plots for 1-, 3-, and 5-year OS and CSS probability showed good consistence between the predicted and the actual events. The decision curve analysis indicated that the nomogram had higher clinical predictive value and more significant net gain than AJCC 6th_TNM stage in predicting OS and CSS of advanced GAC patients with surgery. Cross-validation also revealed good accuracy and stability of the models.ConclusionThe developed predictive models provided available prognostic estimates for advanced GAC patients with surgery. Our findings suggested that both OS and CSS can benefit from chemotherapy or radiotherapy in these patients